Item Pool: Item Room, Secret Room, Greed Mode Item Room. Displays a random cryptic message on the screen similar to the fortune machine ones. Counts as 1 of 3 familiar items needed towards the Conjoined transformation. Counts as 1 of 3 mom items needed towards the Mom transformation. It also doesn't do poison damage despite having the tagline 'toxic aura tears'. The tears caused by Sad Bombs are much larger and do a lot more damage than Isaac's normal tears. UNLOCK: Unlock this item by beating Challenge #13 (Beans!). Doesn't affect coins dropped after waves in Greed Mode. Reveals adjacent room types, this includes revealing if you're next to a Secret Room or Super Secret Rooms. DETAILS REVIEWS MORE *, grey, silver, sword, dagger, blade, knife. Upon use, this item causes Isaac to fart and poison any enemies in close proximity. * item room, treasure room, item room pool, green, cry, plant, Tears now shoot three at a time (Triple Shot). The Leech deals 1.5 contact damage per tick. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor, I can see forever - Opens secret room and super secret room entrances on the current floor, I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only), Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in it, Paralysis - Prevents you from moving for a short while, Pheromones - Applies the charm effect to all enemies in the room for a short while, Puberty - Causes Isaac to grow hair for the rest of the run. 3 Dot - Rerolls all pickups on the entire floor. Does not appear to affect your damage and only the hitbox size of tears. * item room, treasure room, item room pool, grey, gray, asteroid, silver, ball. Item Pool: Item Room, Angel Room, Greed Mode Angel Room. The laser persists for the entire 15 seconds even between rooms and floors. Essentially a one-time use of the Epic Fetus item. Causes all item pedestals to be chosen from a random item pool instead of the pre-defined ones which normally exist. The spike wave will deal 10 damage to any enemies in contact with it. * item room, treasure room, item room pool, luigi board, weeja board, paper, grown. Spawns another Vurp! Gives a 1/3 chance for room clear rewards to become a normal or locked chest, and a 1/3 chance to reward nothing at all. UNLOCK: Unlock this item by defeating Greedier mode with Maggy. *, the lost item pool, pink, red, guts, intestine, tube. A familiar which follows Isaac and shoots lasers, similar to the Technology item. * This used to be a 'special' item in Rebirth that was permanently active, however was downgraded in Afterbirth and onwards. This was nerfed in Afterbirth+, where it simply gives a chance to discount items with each new Steam Sale. When used, farts on nearby enemies and knocks them backwards away from Isaac. * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, Upon use, gives you a duplicate of each familiar you have for the current room. If you get hit while Cursed eye is a solid black colour you are guaranteed to be teleported to another random room on the floor. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins. UNLOCK: Unlock this item by defeating Ultra Greedier as The Forgotten. This item doesn not affect troll bombs - they will still explode. UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson. Randomly increases 4 of your stats, and decreases 2 of them. Displays a random cryptic message on the screen similar to the fortune machine ones. Item Pool: Item Room, Gold Chest, Secret Room, * golden chest pool, gold chest pool, secret room pool, item room, treasure room, item room pool, grey, gray, lamp. Item Pool: Item Room, Greed Mode item Room, When picked up, this item replaces all of your red heart containers with 6 Bone Hearts, Every time you lose a bone heart, lots of bones fire in all directions damaging any enemies hit and you gain a permanent +0.5 Tears Up. I wouldn't call any straight upgrade 'meh', in fact they're absolutely worth it since they're straight upgrades. Does not attract other pickups like the full Magneto item does. the lost item pool. * astrology, astronomy, item room, treasure room, item room pool, blue glow, m. Balances out your main stats to bring the high and low stats closer to an average value. UNLOCK: Unlock this item by beating the Chest with Eden. Teeth shots deal damage equal to your tear damage * 3.2. All the above effects are only active when the item is used for the current room. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room. Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup. Room icons will not show if a Curse of the Lost is in effect on the current floor. * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Allows you to crush Red Poops and sometimes not take damage. * item room, treasure room, item room pool, glass, blue, water. Reveals adjacent room types, this includes revealing if you're next to a Secret Room or Super Secret Rooms. UNLOCK: Unlock this item by beating the Boss Rush with Azazel. Has no recharge time and can be used as often as you like. 3. If an item is chosen from an exhausted pool, it will spawn a Breakfast item instead. Before Afterbirth this was a flat 3.5 damage. The trail of black powder left on the floor will quickly disappear, meaning you are limited on the size of the pentagram symbol you can create. Converts all negative pills into their positive counterparts e.g. - Spawns one blue attack spider for every enemy in the room. the lost item pool, white, blue, cross, jar. Counts as 1 of 3 bum items needed towards the Super Bum transformation. After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. If the effect fails, all pickups and items are deleted and Crooked Penny spawns 1 coin. Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac. UNLOCK: Unlock this item by beating Satan in Sheol 5 times. Gives Isaac a finger which floats infront of him and points in the same direction he is facing or firing. Partial charging does nothing - must be fully charged to use. Item Pool: Item Room, Boss Room, pink, plaster, sticker, * boss room pool, boss room item, item room, treasure room, item room pool, the lost item pool. A familiar which follows Isaac and drops half a red heart every 3 rooms. Use the XIII - Death card item at least four times: The Negative: Defeat Satan for the fifth time: The Parasite: Collect at least two "Head" items in a single run (Bob, Cricket, Tammy, etc) The Polaroid: Defeat Isaac (Boss) for the fifth time: The Relic: Defeat Isaac (Boss) as Magdalene: The Relic: Defeat Isaac (Boss) as Magdalene: The Soul . red, pink, broken. Basement 2: 2 Bombs + 2 Keys. * item room, treasure room, item room pool, jar, bottle, purple, label. Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors. UNLOCK: Unlock this item by beating the Chest with Blue Baby. I gotta disagree on get out of jail card being in a higher bracket than Algiz. If a tear blocks something, both Isaac's and the enemies tears are destroyed. The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time. Will not deal contact damage unless you are moving fast enough (at least 0.8 speed), but does not prevent you from taking damage yourself. Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper. Upon use, this item causes Isaac to fart and poison any enemies in close proximity. Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time. * tinted rock, marked rock, grey, gray, lump, white. Tears become flat and disc shaped giving them a larger hitbox. UNLOCK: Unlock this item by beating the Isaac boss with Eden. This item only costs 1/2 a heart to use if you have The Wafer item. D Rank. Team Nicalis who are the original spriters of the devil door from the game the binding of isaac rebirth Salem who tweaked the devil door sprite. When used, has a 50% chance to drop one random type of coin (penny, nickel or dime). The daze effect is effectively permanent for normal enemies, and has a much longer duration for bosses compared to other status effects. Can be placed over a broken red poop to overwrite it, causing it to no longer regenerate. When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances. * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, Creates copies of pickups, even if you haven't purchased them yet. Isaac has a random chance to fire another tear out the back of his head. * item room, treasure room, item room pool, red, horse shoe. The additional item will pick from the Boss Item Pool. UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue). Synergizes with most items that affect how many tears you fire (20/20, Mutant Spider etc.) the lost item pool, white, black. When used, removes one heart container and gives you 3 soul hearts. UNLOCK: Unlock this item by beating The Chest floor with Keeper. Challenge reward tier list (Afterbirth) While some challenges rewards you with items that can make later runs easier, some can make your runs worse. * shop room pool, shop item pool, purple, paper, ticket, Isaac can now hold 2 cards or runes at once. Using bombs or your active item will remove the invicibility as well. The extra charges appear in yellow on top of the normal green bars. Item Pool: Item Room, Super Lust Miniboss, * item room, treasure room, item room pool, the lost item pool, maggy, starting, 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms). UNLOCK: Unlock this item by beating the Caves II for the first time. Gives Isaac invincibility and +0.28 Speed for 6 seconds. * secret room pool, item room, treasure room, item room pool, grey, gray, shackle. UNLOCK: Unlock this item by beating Satan with Cain. An item only found in the Shop room pool. After you get hit the Stop Watch applies a slowing effect for the rest of the room to all enemies and their projectiles. Teleports Isaac to a random location on the map. Soy Milk) can lead to interesting synergies. Boom Fly, Red Boom Fly, Drowned Boom Fly move slower, but still deal contact damage. When used will teleport you to another random room that has not been explored yet. Isaac's touch now petrifies enemies, turning them to gold for a few seconds. -35% Damage Down (0.65 damage multiplier). arrow. 10 Of The Best Items In The Binding Of Isaac Players will have to be quick to get the item they have their eye on, however, as the pedestal cycles through its items very quickly. * secret room pool, item room, treasure room, item room pool, bag, purple, pouch. When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone. Tears Down significantly (Tear delay * 2.1 + 3). The fly orbits a lot faster than Distant Admiration or Forever Alone and deals 5 damage per tick. Has no effect on most familiars that scale with Isaac's tear damage. UNLOCK: Unlock this trinket by defeating ??? UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black). Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period. * technology.5, item room, treasure room, item room pool, white, red, eye, robot. When used, copies the effect of the card or rune you are currently holding without consuming it. purple, pink, mask, face. Isaac's tears slow down over time while moving across the room, and upon stopping completely or hitting an object will burst into 8 smaller tears which fire in all directions. Creates a trapdoor on the floor (Same effect as We Need To Go Deeper). Every time you take damage, 10 high damage tears are fired in a circle around you (similar to the Tammy's Head effect). Item Pool: Item Room, Secret Room, Greed Mode Shop, *, red, yellow, green, white, square, rectangle. Gives you an increased chance of finding battery consumables. Causes you to become immune to explosions. In Afterbirth this item has a 20% chance to cause enemies to drop black hearts if it was poisoned. Allows game breaking combinations with the Jera rune by chaining batteries and pickups and using it multiple times. Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each. Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies. This dash makes Isaac invulnerable and is more controllable than the dash granted by the Aries item. * item room, treasure room, item room pool, gameboy, grey, gray, white. - Tears will shoot diagonally for about 60 seconds. * boss room pool, boss room item, sticks, brown, yellow, * angel room pool, god room pool, angel room item, the lost item pool, cup, wooden, gold, Maintains momentum if you are already moving in the same direction. Added as part of the Afterbirth+ Booster Pack #5. A spacebar item that fires 8 of Isaac's tears in a circle around him. UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby. UNLOCK: Unlock this item by beating Dark Room with The Lost. UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon). Creates a friendly blue spider when you kill an enemy. Sister Maggy fires tears at a rate of 1 tear per second. * boss room pool, boss room item, item room, treasure room, item room pool, black, baby, white, eyes. A white orbiting fly which deals 3 contact damage per tick to enemies. Added as part of the Afterbirth+ Booster Pack #4. the lost item pool, purple, cross, * curse room pool, devil pool, devil room pool, devil deal, red, 666, * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract, In general if a card has a number of things, that thing is doubled. * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, When used, rerolls all enemies in the room which are currently alive into another random type of enemy from any floor. It's main focus was to give players modding tools as well as another huge content patch. grey, gray, blue. The cloud deals damage equal to your base tear damage per tick, roughly 5 times per second. Item Pool: Library, Secret Room, Devil Room, * library pool, library room, book room pool, secret room pool, devil pool, devil room pool, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, If used with Brimstone you have a 100% chance to fire a laser out the back of your head. Turns your tears into bones, which shatter into 1-3 smaller bone shards upon hitting any object or enemy. If you take damage which leaves you at 1/2 a heart, you gain a Little Steve familiar that follows you and shoots homing tears. Exclusively drops from one of the horsemen bosses. When picked up, and at the start of each floor this rerolls all your current items, giving you a new item to replace each of the ones you had. A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts. At the start of a new floor, you get an eternal heart. Each flame deals 125 total damagebefore it disappears. Can also cure the effect of the Amnesia pill. Time is the essence", "Sleeping gatekeepers will need to be awoken with a loud sound". Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies. If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal a lot more damage. * item room, treasure room, item room pool, white, ball, dripping. It is possible to generate multiple meatboys by stacking more than 4 Cubes of Meat. After all the normal rooms have been explored, the hierarchy of rooms chosen is: Super Secret Room, Shop, Item Room, Sacrifice Room, Dice Room, Library, Curse Room, Miniboss, Challenge Room, Bedroom, Arcade, Vault, Secret Room, Devil/Angel Room, I AM ERROR. * arcade, skull game, black, heart, pink, love. Isaac's tears become homing and have a large aura around them, which will deal damage to anything inside its radius. A familiar that follows isaac around dropping white creep which slows down enemies that walk over it. Can create up to a maximum of 5 spiders in the room at one time. Grants the same effect as 'My Little Unicorn', which makes Isaac invincible and deal 40 contact damage to enemies per hit. Using this item gives you a higher chance of finding a horsemen boss at the end of the floor. Before Afterbirth this was a flat 5 damage per tick. trinket (e.g. When used, replaces all pedestal items in the current room with another random item. XI -Strength Upon use, increases all of Isaac's stats except tears and adds one (temporary) heart container for the current room. * angel room pool, god room pool, angel room item, white, blue, ball, circle. (Does not roll your devil deal items). Upon use, gives Isaac an extra Soul heart. Donating to a Donation Machine has a chance to heal Isaac for a full red heart or spawn a Beggar. Counts as 1 of 3 syringe items needed towards the Spun transformation. Decreases range stat by -4.25 but increases your tear height by 1.5, increasing your actual tear range. * astrology, astronomy, item room, treasure room, item room pool, blue, glow. 4. Team Nicalis who are the original spriters of the devil door from the game the binding of isaac rebirth Salem who tweaked the devil door sprite. Still nice to have it if you're doing different-character-streak. Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac. * , the lost item pool, nes, game, grey, gray. This spawns friendly charger enemies and causes Isaac to deal 2 contact damage (same as the shade did). This is one of the items which allows you to transform into Guppy. UNLOCK: Unlock this item by beating the Chest with Maggy. item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag. * item room, treasure room, item room pool, deathstar, death star, dice pip, white, circle, sphere. UNLOCK: Unlock this item by beating the Chest with Isaac. Item Pool: Item Room, Library, Devil Room, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, red 7 book, grey, gray, black. Increases your chances to find an Angel Room instead of a Devil Room. UNLOCK: Unlock this item by beating Satan with The Lost. Get out of jail can give you free mega satan access which is super helpful. * angel room pool, god room pool, angel room item, yellow, blue, red, triangle, all seeing eye. The bomb deals 50 damage on hit and leaves a damage over time poison effect that does 3 times your tear damage per tick. UNLOCK: Unlock this item by beating Blue Womb (Hush) with Samson. Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one. * , the lost item pool, tong, red, bloody, lips. For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purle appearance. the lost item pool, white, blue, cross, jar. While held, this trinket gives a random mushroom effect each room. pill if no other pills were used yet. Void does not work on devil deal or shop items unless they have been bought first. Possible tear effects: 20/20, Ball of Tar, Dark Matter, Death's Touch, Fire Mind, Iron Bar, Mom's Contacts, My Reflection, Mysterious Liquid, Number One, Ouija Board, Proptosis, Sagittarius, Scorpio, Speed Ball, Spoon Bender, The Inner Eye, Tough Love. UNLOCK: Unlock this item by donating 150 pennies to the Shop. The poison deals your current tear damage per tick. Charm deals 5 damage. *, flat, white, grey, gray, blue, drip, water, eyes. After taking damage, if you have half a red heart or less, The Negative will deal 40 damage to all enemies in the room. E. Coli turns normal enemies into poop if they touch you. grey, gray, green, mouth. 4 Dot - Rerolls all pedestal items on the floor. An item only found in the boss room pool. Gives Isaac a higher chance to find keys and chests. Half hearts heal a whole heart and full hearts heal 2 red hearts. The chance to drop hearts is affected by your luck stat and at +29 Luck it will activate 50% of the time. +17.5% chance of a Devil Deal opening after the boss fight (Before afterbirth this was 35% chance). Teleports the player to the Boss room on the current floor. Automatically gives you 1 bar of charge after using your spacebar item. * item room, treasure room, item room pool, mm sweet lemonade, urine, yellow, tear, drop, x1.5 times Damage Multiplier if you also have Book of Belial (Does not stack with Magic Mushroom or Cricket's Head multipliers), * item room, treasure room, item room pool, crown, thorns, brown, hat. UNLOCK: Unlock this item by beating the Isaac boss with Eve. * anti gravity, item room, treasure room, item room pool, anti gravity, atom, nucleus. purple, pink, circle. * astrology, astronomy, item room, treasure room, item room pool, m, tail, blue, glow. Item Pool: Item Room, Super Sloth Miniboss, Bomb Beggar, * boss rush pool, boss rush room, item room, treasure room, item room pool, bob sloth, A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage. After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected. UNLOCK: Unlock this item by beating the Chest with Eve. Gives Isaac a higher chance to find hearts from drops after clearing a room and from chests. Causes your tears to become piercing, allowing them to travel through enemies. Item Pool: Item Room, Gold Chest, Secret Room, * golden chest pool, gold chest pool, secret room pool, item room, treasure room, item room pool, Causes Isaac's head to detach and orbit his body, blocking shots and dealing 7 contact damage per tick. When used, makes Isaac leap in the air, similar to the leaper enemies. Can drop any kind of heart, coin, bomb or key. Using Void to absorb items in Boss Rush or Challenge Rooms counts as taking the items and will cause the encounter to start. Your tears now whip across the room at a very high shot speed. Contrary to popular belief, the Bible Tract doesn't allow Angel Rooms to appear after paying for a Devil Deal. Causes pickups on the floor move towards the player. Purity will boost one of Isaac's stats depending on the colour of the aura around him. Lowers your spacebar item charge rate by 1. pants, under wear, pink, knickers, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, high, shoe, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, grey, gray.
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