doi: 10.1016/j.it.2016.01.004, 29. I lead the sales and estimating side of the business. In addition, determining optimal combination therapies likely depends on multiple factors including patient's condition, tumor type, stage and composition of the TME.
doi: 10.1016/j.ccell.2014.09.007, 35. Baumeister SH, Freeman GJ, Dranoff G, Sharpe AH. (2016) 7:550. doi: 10.3389/fimmu.2016.00550, 105. Anti-CTLA-4 immunotherapy does not deplete FOXP3+ regulatory T cells (Tregs) in human cancers. This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Ann Transl Med. J Thor Oncol.
Cyclophosphamide is an alkylating agent that has tumoricidal effects, thereby reducing tumor burden (72). Here, we show that orthotopic liver metastasis mouse models of pMMR CRC cell lines are unresponsive to ICB and recapitulate the resistance of human disease, unlike . This two volume set provides a comprehensive account of the entire sequence of operations involved in discovering a drug through the actual delivery of the drug to clinicians and medical practitioners. Explore the benefits of becoming a member.
Found inside – Page 474... Medicines Safety, Drug Safety and Metabolism, iMeD Biotech Unit, AstraZeneca, pepparedsleden 1,431 83 Mölndal, Gothenburg, Sweden; bproQR Therapeutics BV, Zernikedreef 9, 2333 Ck leiden, The Netherlands *e-mail: patrik.J.Andersson ... In addition, depletion of immunosuppressive cells in the TME renders the TME more receptive for tumor-specific T-cell infiltration upon DC-therapy. Tatsuta K, Tanaka S, Tajiri T, Shibata S, Komaru A, Ueda Y, et al. Cancer Immunol Res. Teitz-Tennenbaum S, Li Q, Okuyama R, Davis MA, Sun R, Whitfield J, et al. She joined the Research Enhancement Award Program as an Assoc Investigator at San Francisco VA Medical Cntr where her research focused on miRNA dysregulation in prostate cancer. J Immunol. (2007) 44:2558–65. Lesterhuis WJ, de Vries IJ, Aarntzen EA, de Boer A, Scharenborg NM, van de Rakt M, et al. (2013) 62:285–97. However, in pancreatic cancer patients, despite decreased PD-1+CTL numbers in responders, the concurrent combination did not result in decreased MDSC and Treg numbers in responders vs. non-responders (64). Roeven MW, Hobo W, van der Voort R, Fredrix H, Norde WJ, Teijgeler K, et al. doi: 10.1158/2159-8290.CD-15-0283, 13. Logga in på Hotmail eller Outlook.com. The antagonistic antibodies ipilimumab and tremelimumab are designed to target CTLA-4, an inhibitory pathway that inhibits activation of naïve T-cells by preventing the binding of CD28 on T-cells to CD80/CD86 on APCs, a mechanism widely exploited by Tregs (124, 125). Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. He joined the BfArM (Federal Institute for Drugs and Medical Devices, Bonn, Germany) in 2000. (1991) 9:271–296. Blockade of PD-1 on DCs improves survival while blockade of PD-L on tumor cells results in improved tumor-cell infiltration and killing.
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By clicking SUBSCRIBE, you are agreeing to our. She has been at GSK since 1981 in a variety of chemistry and CMC Regulatory roles. Oncoimmunology (2018) 7:e1412901. For example, treatment of tumors enriched with Tregs should entail combinations with Treg-depleting chemotherapeutics, whereas DC-therapy should be combined with PD-L1 antagonistic antibodies in tumors with high PD-L1 expression. He was a post-doc fellow at Parke Davis, Ann Arbor MI, depart. Morten Gram Pedersen. J Immunol. mRNA-transfected dendritic cell vaccine in combination with metronomic cyclophosphamide as treatment for patients with advanced malignant melanoma. J Thorac Oncol. 68. Patrik Ripadal Head of Security & Safety/ Risk Manager /Senior Advisor / Certified board member Gøteborg og omegn. He is a founding member of OND’s Pharmacology/Toxicology Oligonucleotide Subcommittee, which considers issues specifically related to the safety review of oligonucleotide-based therapeutics. En spruta laddas med Covid-19 vaccin från Astra Zeneca ( AstraZeneca ) vid SUS vaccinationcentral i Malmö. Starting from October 1 this year, Stellan will work in . Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. Similar results were obtained when combining DC-therapy with a CD40-agonistic antibody, capable of converting macrophages to a proinflammatory phenotype, and further stimulating the CD40+DCs (133). (2014) 7:1389–96.
Please enable it to take advantage of the complete set of features! Activation and maturation of DCs are induced upon exposure to environmental stimuli including damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), leading to enhanced expression of co-stimulatory molecules, cytokine production, reduced phagocytosing capacity, and improved T- and B-cell activation (5, 6). Depending on the type of DC-therapy used, long-term clinical efficacy upon DC-therapy . Nettiauto on Suomen suurin ja suosituin ajoneuvojen kauppapaikka. Don't miss an opportunity - join our mailing list to stay up to date on DIA insights and events. He currently serves as a CMC reviewer and is Deputy Head of the Unit Pharmaceutical Biotechnology. Front Immunol. Immunity (2018) 48:399–416. Clin Cancer Res. (2017) 114:E4223–32. Epub 2020 Oct 21. Kiinnostavimmat uutis- ja ajankohtaissisällöt koti- ja ulkomailta. Sponaas AM, Moharrami NN, Feyzi E, Standal T, Holth Rustad E, Waage A, et al (2015). Already a DIA Member? Sisäministeriön selvityksessä hahmotellaan, että oleskelulupa myönnettäisiin vuosina 2015-16 saapuneille turvapaikanhakijoille, jotka ovat olleet maassa pitkään ilman oleskelulupaa. Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity. Clipboard, Search History, and several other advanced features are temporarily unavailable. Lennart K Andersson, PSP, cATO Security Manager at AstraZeneca Sverige. However, most promising clinical results were obtained by a recent study, in which the overall response rate reached 38% in advanced melanoma patients. However, failure to predict acute kidney injury induced by SPC5001 ASO observed in a clinical trial suggests the need for additional preclinical models to complement the preceding animal toxicity studies.
doi: 10.1038/nri.2016.107, 47. Gå med för att skapa kontakt However, whether the effects observed on NK cells were associated with depletion of Tregs remains elusive. Bhattacharyya T, Purushothaman K, Puthiyottil SS, Bhattacharjee A, Muttah G. Immunological interactions in radiotherapy-opening a new window of opportunity. DCs can be loaded with different sources of tumor antigens, such as mRNA, peptides, proteins or whole tumor cell lysate (5, 37). DC-mediated T-cell activation is initiated by antigen presentation on major histocompatibility class (MHC) I and II and further guided by co-stimulation and secretion of cytokines (7–9). Keywords: Garg AD, Coulie PG, Van den Eynde BJ, Agostinis P. Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape.
Dr. Elena Braithwaite is a toxicologist at the US Food and Drug Administration and a Diplomate of the American Board of Toxicology.
Emadi A, Jones RJ, Brodsky RA. (2016) 168:74–95. 129. Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the cationic lipid SAINT-18. Research Funding: Genentech (Inst), Boehirnger Ingelheim (inst). In clinical trials with patients suffering from hepatocellular carcinoma and high-risk sarcoma, combining intratumoral injection of unloaded DCs with radiotherapy induced tumor-specific immunity in 70 and 52.9% of the cases, respectively (89, 90). Role of T lymphocytes in tumor response to radiotherapy. 1. (2017) 5:535–46. Patrik Andersson Director RNA Therapeutics Safety at AstraZeneca Gothenburg Metropolitan Area. She investigated the therapeutic application of siRNAs. These results underline the importance of PD-L1 expression on DCs in inhibiting anti-tumor immunity. In order to circumvent tumor-induced suppressive mechanisms and unleash the full potential of DC-therapy, considerable efforts have been made to combine DC-therapy with chemotherapy, radiotherapy or with checkpoint inhibitors. Cancer Cell (2015) 28:690–714. This could be due to reduced CTL numbers caused by TMZ-induced lymphoablation, thereby counteracting the effects of DC-therapy, as shown by a recent study (63). In addition, cyclophosphamide and temozolomide deplete Tregs and induce lymphoablation upon treatment with low-dose or high-dose, respectively.
This manual makes the process of managing responsibilities to and relationships with stakeholders and nature explicit. (2013) 4:417. doi: 10.3389/fimmu.2013.00417, 24. Table 1. Bethesda North Marriott Hotel and Conference Center, Therapeutic Innovation & Regulatory Science Journal, Diversity, Equity, and Inclusion Statement, Ionis Pharmaceuticals, Inc., United States, Associate Director for Pharm/Tox ODE3, CDER, Executive Vice President, Chief Medical Officer and Head, Regulatory Affairs, Intellia Therapeutics, Inc., United States, Vice President, Analytical and Process Development, CMC Tyndall Consultant LLC, United States, Deputy Head of the Unit Pharmaceutical Biotechnology BfArM, Federal Institute for Drugs and Medical Devices, Germany, Principal Scientist, Discovery Safety Specialist, UT Southwestern Medical Center at Dallas, United States, Executive Vice President, Research and Development, Pharmacologist, Office of New Drugs, CDER. (2017) 27:326–34.
Semin Immunol. Bol KF, Schreibelt G, Gerritsen WR, de Vries IJ, Figdor CG. Search for more papers by this author, Joel D. Parry. Speakers at this event. doi: 10.1016/j.leukres.2009.01.007, 112.
85. Blankenstein T, Coulie PG, Gilboa E, Jaffee EM. Received: 31 August 2018; Accepted: 09 November 2018; Published: 05 December 2018. This indicates that blockade of PD-1 or PD-L1 on DCs could enhance anti-tumor immunity in vivo via multiple ways. Chambers CA, Kuhns MS, Egen JG, Allison JP. Dendritic cells (DCs) are antigen-presenting cells (APCs) that are essential for the activation of immune responses. Bardhan K, Anagnostou T, Boussiotis VA.
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy William W. Hoa,b,1, Igor L .
For instance, tumor reduction by neo-adjuvant chemotherapy could improve DC-therapy, as DC-therapy is most effective in cases of low-tumor burden (31). doi: 10.1016/j.immuni.2013.07.012, 19. Found inside – Page 99... Allgon Factory 1st prize invitational competition completed building 2000 AstraZeneca , research facility Waltham ... Nils Gulin Anna Karin Andersson 2 Lennart Gullberg 2 Magnus Börjesson 2 Vera Knihova 2,3,4 Per Glembrandt 4,5,7,8 ... (2005) 65:1089–96. Oncogene (2017) 36:6143–53. This volume will be of interest to scientists and engineers developing pulmonary drug delivery systems. (2015) 112:6140–5. During extended exposure for up to 20 consecutive days, only SPC5001 induced cytotoxicity (at the higher concentration; 5 µM), as evaluated by LDH in the perfusate medium. Patrik Jonsson Regional Compensation Partner Norrköpingsområdet 135 kontakter. doi: 10.1038/nri3712, 3. Cancer Immunol Immunother. Ange din e-postadress eller ditt telefonnummer och välj Nästa. AstraZeneca är en mycket stor arbetsplats. Hein Espen Hattestad. Dr. Wange is a Supervisory Pharmacology/Toxicology Reviewer within the Office of New Drugs in CDER at the FDA, and has over 12 years of experience reviewing small molecule drugs, biotherapeutic proteins and oligonucleotide-based therapeutics. Cell Mol Life Sci. A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatin/capecitabine chemotherapy in colon cancer patients. J Investig Med. Here, we show that orthotopic liver metastasis mouse models of pMMR CRC cell lines are unresponsive to ICB and recapitulate the resistance of human disease, unlike . However, mismatch repair-proficient (pMMR) metastatic colorectal cancer (CRC), ∼95% of total metastatic CRC cases, typically does not respond to ICB. Radiat Oncol. doi: 10.3892/ijo.31.3.509. However, despite these attempts to improve DC-therapy, combinatorial strategies are essential to prorogue suppressive mechanisms in the TME and to further potentiate the clinical efficacy of DC-therapy. We are dedicated to being in a class of our own, we achieve this by modernizing the industry and creating a new level of customer service. Clinical and CTL responses were also not associated in a clinical trial with 16 melanoma patients treated with MART-1 peptide loaded DCs and tremelimumab (130). Hegmans JP, Veltman JD, Lambers ME, de Vries IJ, Figdor CG, Hendriks RW, et al. But we're more than one of the world's leading pharmaceutical . Low-dose cyclophosphamide synergizes with dendritic cell-based immunotherapy in antitumor activity. Lee TH, Cho YH, Lee JD, Yang WI, Shin JL, Lee MG. Immunomodulatory effect of DC/CIK combined with chemotherapy in multiple myeloma and the clinical efficacy. Cytotherapy (2017) 19:500–13. Borch TH, Engell-Noerregaard L, Zeeberg Iversen T, Ellebaek E, Met Ö, Hansen M, et al. This leads to insufficient antigen presentation, T-cell anergy and decreased T-cell proliferation, thereby restricting effective anti-tumor immunity (16–18). She received a BS in Biology from State Univ of New York in 01’, a PhD in Cell Biology from Univ of Connecticut in 06’. Careers. Dr. Rogers completed his Pharm.D. J Exp Med. Immunol Res. Crossref, Medline, Google Scholar; 22. Unable to load your collection due to an error, Unable to load your delegates due to an error. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications ... doi: 10.1056/NEJMoa1001294, 33. doi: 10.1007/s00262-004-0629-2, 60. Found inside – Page 67128. published: 10 September 2018 doi:10.3389/fonc.2018.00367 Edited by: Patrik Andersson, Massachusetts ... or Advisory Role: Bristol-Myers Squibb, MSD Oncology, Boehringer Ingelheim, Eli-Lilly, Roche Speakers Bureau: AstraZeneca. However, more recent insights indicate that chemotherapy also has off-target immunological effects depending on the type of chemotherapy, such as immunogenic cell death (ICD) of tumor cells, thereby enabling the induction of anti-tumor immunity (44). (2015) 13:139. doi: 10.1186/s12967-015-0473-5, 69. Nat Immunol. Bracci L, Schiavoni G, Sistigu A, Belardelli F. Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer.
doi: 10.1016/j.ccell.2015.10.012, 45. Patients were randomly assigned in a 1:1 ratio within their stratum to receive budesonide-formoterol (Symbicort, AstraZeneca) through an open-label inhaler (two actuations of 80 μg of . Ge W, Ma X, Li X, Wang Y, Li C, Meng H, et al. doi: 10.1007/s00262-007-0305-4, 53. Further investigation into these combinations in different (pre)clinical models could lead to promising novel combination strategies. (2009) 183:3634–41. doi: 10.4049/jimmunol.181.5.3099, 96.
Kaikki vaihtoautot ja uudet autot. A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer.
Det är lätt att automatiskt arkivera e-postmeddelanden och dela foton. Prior to that, she was a clinical analyst and SME in the Federal Healthcare Practice at Deloitte Consulting LLP and her projects were focused on post-marketing drug safety and review modernization effort at OGD. These differences could be explained by differences in sampling time, as reduction in Tregs was evaluated after the first cyclophosphamide treatment in mesothelioma patients (56), whereas in melanoma patients, these levels were assessed after 4 and 6 cycles of DC-therapy (57). Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer. In patients with advanced melanoma, administration of one TMZ cycle prior to each DC-therapy decreased circulating Tregs with 60.5% (60). IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity. The induction of systemic anti-tumor immunity was indeed observed when radiotherapy was combined with GM-CSF as it generated abscopal effects in some patients (81). Nat Rev Cancer (2012) 12:307–13. Interestingly, this study also illustrated that, in contrast to CTL numbers, NK cells in peripheral blood remained constant after concurrent combinations with TMZ. Gemcitabine is able to improve anti-tumor immunity by depletion of MDSCs and Tregs (Figure 1) (47, 48, 75). J Immunother. Co-administration of oxiplatin, capecitabine and DC-therapy in colon cancer patients induced proliferation of KLH-specific CD4+ T-cells in all patients as well (66). Nat Rev Clin Oncol. Kausi 11, 10/26. En singelolycka har inträffat på E22 norr om Tollarp i södergående riktning. Patrik Andersson, PhD • Principal Scientist, Discovery Safety Specialist AstraZeneca R&D, Sweden Fran Wincott, PhD • President Wincott & Associates LLC, United States Elena Braithwaite, PhD • Toxicologist FDA, United States As this trial has no control arm no conclusions on synergy can be made. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. Carreno BM, Becker-Hapak M, Huang A, Chan M, Alyasiry A, Lie WR, et al. Hali S Sylinen / Patrik Hevonen. (2018) 20:1566–72. In addition, cyclophosphamide initiates ICD and transient lymphoablation upon high doses, thereby resulting in depletion of suppressive immune cells and stimulation of anti-tumor T-cell responses.
In addition, cytotoxicity of CTLs improved when PD-1 was inhibited in a co-culture of tumor cells and T-cells isolated from mice treated with DC/myeloma fusions (106). However, in recurrent glioblastoma patients, where DC-therapy was followed by TMZ administration, combined treatment failed to improve 6-month PFS compared to a reference group with TMZ monotherapy (62). doi: 10.1093/intimm/dxu076, 126.
Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Since year 2000, it is the . I was employed as a Research Engineer at Stora Enso AB, Innovation Centre in Nacka. Antonios JP, Soto H, Everson RG, Orpilla J, Moughon D, Shin N, et al. Copyright © 2018 van Gulijk, Dammeijer, Aerts and Vroman. (2016) 22:1856–64. Spranger S, Bao R, Gajewski TF. doi: 10.1007/s12026-017-8931-1, 6. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice. (2007) 123:298–310. Det framgår av analyser från bankerna. Gato-Cañas M, Zuazo M, Arasanz H, Ibañez-Vea M, Lorenzo L, Fernandez-Hinojal G, et al. doi: 10.1016/j.smim.2008.09.006, 39. Furthermore, this indicates that TMZ administration before or during DC-therapy could enhance DC-therapy efficacy, whereas DC-therapy followed by TMZ may exert negative effects on DC-induced anti-tumor immunity. Kumar V, Patel S, Tcyganov E, Gabrilovich DI. doi: 10.1073/pnas.1609376113, 15. 67. Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. J Transl Med. Clin Cancer Res. His experience is in the field of formulation, manufacture and control of medicinal products, in particular in the field of peptides, proteins, liposomes, sustained release polymer drug products, depot formulations, polymer-conjugated drug products, natural and synthetic surfactants, nanomedicine and others. (2014) 20:117–23. doi: 10.1038/nm863, 111. J Exp Med. doi: 10.1080/2162402X.2017.1412901, 64. RNA Therapeutics Safety Lead at AstraZeneca. Park SJ, Namkoong H, Doh J, Choi JC, Yang BG, Park Y, et al. Moreover, perfusate levels of biomarkers KIM-1, NGAL, clusterin, osteopontin and VEGF increased 2.5 ± 0.2-fold, 3.9 ± 0.9-fold, 2.3 ± 0.6-fold, 3.9 ± 1.7-fold and 1.9 ± 0.4-fold respectively, in response to SPC5001, generating distinct time-dependent profiles. The PD-1/PD-L-axis exerts negative effects on TME-infiltrating immune cells by inhibiting T-cell effector functions, NK cells and inducing T-cell exhaustion (101–104). Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Karachi A, Dastmalchi F, Mitchell D, Rahman M. Temozolomide for immunomodulation in the treatment of glioblastoma. doi: 10.1080/14737175.2016.1202761, 74. 82. Astra Zeneca. This website uses cookies. Timing of treatment administration should be taken into consideration in these studies as it could affect the efficacy of combination therapies. Tel J, Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, et al. Dr. René Thürmer received his diploma in chemistry and his Ph.D. in biochemistry from the University of Tübingen. doi: 10.1016/j.ijrobp.2010.12.068, 91. doi: 10.1172/jci.insight.87059, 109. doi: 10.1038/nature14320, 40. (2013) 123:3383–94. Source: Patrik Andersson expand_more. Currently a Chemist at FDA/CDER, has been with FDA since 2003. Electronic address: Kyrre.Thalberg@astrazeneca.com. Nonclinical Safety, GSK R&D, David Jack Centre for R&D, Ware, United Kingdom. Pellegatta S, Eoli M, Cuccarini V, Anghileri E, Pollo B, Pessina S, et al. Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, et al. doi: 10.1002/ijc.22377, 44. Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression. (2013) 123:2355–7. Nyheder, breaking news og de store perspektiver, analyser og læseoplevelser. His special focus lies on oligonucleotide preparations. (2016) 37:855–65. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether . J Immunol. In addition, specific chemotherapeutics can directly deplete suppressive immune cells including Tregs and MDSCs (47–49). Precast HQ is a precast concrete manufacturer based in Auckland, New Zealand. In the newly-diagnosed patients, PFS and OS were improved compared to an international trial of TMZ monotherapy (61). Quantitative abdominal fat estimation using MRI. Nature (2015) 523:231–5. - Det finns uppgifter om att det är superhalt på platsen, säger Sara Andersson, polisens presstalesperson i region Syd.
doi: 10.1097/CJI.0b013e3181a95165, 87. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. PD-L1 blockade on DCs improved maturation and proliferation of DCs during culture, inhibited tumor outgrowth and prolonged survival compared to mice treated with DCs on which PD-L1 was not blocked (109). I have been working in a large prioritized R&D project around dissolving pulp with a focus on regenerated fibre products. Liu Y, Cheng Y, Xu Y, Wang Z, Du X, Li C, et al. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. (2011) 6:1162–8. Founder and Commercial Director of Precast HQ. Articles Cited by Public access Co-authors. Sarjan on luonut meribiologi Stephen . Cancer Cell (2014) 26:638–52. (2017) 27:109–18. Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. doi: 10.1038/sj.bjc.6605935.
Akasaki Y, Kikuchi T, Homma S, Koido S, Ohkusa T, Tasaki T, et al. Also the percentages of DCs that migrate successfully toward the lymph nodes is limited, with up to 4% of injected DCs reaching the lymph node after intradermal injection and 0–56% reaching the lymph node after intranodal injection (26). J Immunother. Clin Cancer Res.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 2016 Nov 5;790:46-56. doi: 10.1016/j.ejphar.2016.07.018.
Prue RL, Vari F, Radford KJ, Tong H, Hardy MY, D'Rozario R, et al. Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J, Kortesmaa J, Mercer A, Nielsen E, Rönnholm H, Wikström L. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. Adler M, Ramm S, Hafner M et al (2016) A quantitative approach to screen for nephrotoxic compounds in vitro. Banker ser köpläge i Astra Zeneca efter rapportsvackan. Oncoimmunology (2018) 7:e1395124.
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